The team is planning to announce his replacement at an 11:30 a.m. ET news conference on Monday.
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Milwaukee’s move comes just 25 games into the season, but the Brewers (7-18) are currently the worst team in baseball. They were 341-331 in Roenicke’s four-plus years as manager.
Brewers general manager Doug Melvin said in a statement that the team’s decision to fire Roenicke went beyond its record.
“This has been a difficult start to the season, something that we did not anticipate,” Melvin said. “Over roughly the last 100 games, we have not performed at the level that we should. … The reasons for our disappointing start are many, but we determined it’s in the best interests of the club to make this move.”