Specific DNA mutations may increase a person’s risk for cancer, including adrenocortical carcinoma. However, having a specific genetic condition doesn’t mean you’ll necessarily develop this type of cancer. Evidence suggests that this cancer is more common in children than adults.
This article will explore the causes and risk factors for adrenocortical carcinoma, including genetics.
Common Causes
Unfortunately, experts don’t know what causes adrenocortical carcinoma, a rare form of cancer.
Genetics
It’s possible that genetics play a part in the development of adrenal cortex tumors. Genetic conditions that may be linked to adrenocortical carcinoma include the following.
Li-Fraumeni Syndrome
Li-Fraumeni syndrome is caused by an inherited mutation that turns off the TP53 gene responsible for tumor suppression. This can lead to adrenocortical carcinoma and other adrenal cancers in children and adults. However, it’s more likely to cause adrenal cancer in children. Nearly eight in 10 cases of childhood adrenal cancer involve this genetic syndrome.
It’s important to note that having this genetic syndrome may increase your risk of developing other types of cancer, as well.
Beckwith-Wiedemann Syndrome
Beckwith-Wiedemann syndrome is a genetic condition that causes people to have large tongues and body sizes. Having it can also increase your risk of developing adrenal cortex cancer, among other cancers.
Osteosarcoma (bone cancer) Breast cancer Central nervous system tumors such as neuroblastoma Soft tissue sarcoma Acute leukemia (blood cancer)
People with this syndrome have a 50% chance of developing cancer before they turn 40.
This condition very rarely causes adrenocortical carcinoma, and when it does, it’s usually in children.
Familial Adenomatous Polyposis (FAP)
Without prompt treatment, people who have familial adenomatous polyposis, a genetically inherited disease, will inevitably develop cancer, including adrenal cancer.
People with FAP are more likely to develop other forms of cancer than they are to develop adrenocortical cancer, though.
Lynch Syndrome
Lynch syndrome is another hereditary syndrome that increases a person’s risk of developing several cancers, including adrenal cortex cancer. Evidence suggests that this syndrome accounts for only 3% of adult adrenocortical carcinoma cases, however.
Multiple Endocrine Neoplasia (MEN1)
Multiple endocrine neoplasia is a genetic syndrome in which you’re likely to develop tumors on your pituitary, parathyroid, and pancreas glands. According to the American Cancer Society, approximately 33% of people with MEN1 also develop benign (noncancerous) tumors of the adrenal glands.
Blood in the stoolDiarrheaProlonged constipationAbdominal crampingGas, bloating, and a feeling of fullnessUnexplained weight lossVomitingLethargy
This genetic syndrome is rarely a cause for adrenocortical carcinoma, which represents fewer than 2% of all adult cases, according to a 2014 review.
Von Hippel-Lindau Syndrome
Von Hippel-Lindau syndrome (VHL) is an inherited condition. People with VHL are at higher risk for a rare tumor affecting the adrenal glands called pheochromocytoma. This type of tumor can present similarly to adrenocortical carcinoma and can affect the adrenal cortex if it spreads.
Carney Complex
According to the National Cancer Institute, having Carney complex is another risk factor for developing adrenocortical carcinoma. However, there exist few documented cases in which a person with this syndrome has developed adrenal cortex cancer.
In people with VHL, the tumor is rarely malignant and usually is easy to treat. However, even if the tumor isn’t malignant, it can cause problems if left untreated.
Lifestyle Risk Factors
While having diseases or syndromes that cause genetic mutations can increase your risk of developing cancer, gene mutations can also happen on their own for various reasons.
There’s no direct evidence that certain lifestyle factors can cause adrenocortical carcinoma. However, some lifestyle habits may increase your risk of developing cancers like adrenocortical carcinoma.
According to the American Cancer Society, these include:
Being overweightSmokingLack of physical activityExposure to cancer-causing substances
Summary
Adrenocortical carcinoma is a rare cancer that has no common cause. Certain genetic syndromes can increase your risk of developing it, as can some general lifestyle risk factors.
A Word From Verywell
If you have a family history of genetic conditions or syndromes associated with adrenocortical carcinoma, you may wish to undergo genetic testing and counseling.
However, just because you have one of these genetic syndromes, have a family history of adrenocortical carcinoma, or have certain lifestyle habits linked to cancer, doesn’t mean you’ll automatically develop cancer. Ultimately, experts still have a lot to learn about the causes of this rare cancer.
